MolNFT v1 · #31917 · protein
Crystal structure of the N-terminal MDIA1 armadillo repeat region and dimerisation domain in complex with the MDIA1 autoregulatory domain (dad)
2BAP · Diaphanous protein homolog 1: “Crystal structure of the N-terminal MDIA1 armadillo repeat region and dimerisation domain in complex with the…”. X-ray diffraction, 9 pockets (best druggability 0.50). MolNFT v1 #31917 on GenesisL1: 3D…
- PDB
- 2BAP
- Type
- protein
- Length
- 621 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Diaphanous protein homolog 1
- UniProt
- O08808
- Pockets
- 9 · best druggability 0.50
Structure
x-ray diffraction · 3 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Diaphanous protein homolog 1 | protein | 294 | 72% helix, 0% strand | O08808 |
| A | Diaphanous protein homolog 1 | protein | 295 | 72% helix, 0% strand | O08808 |
| D, C | Diaphanous protein homolog 1 | protein | 16 | 56% helix, 0% strand | O08808 |
Pockets
9 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 172 | 0.50 | 0.78 | 25 | empty |
| 2 | 154 | 0.48 | 0.77 | 23 | empty |
| 3 | 84 | 0.45 | 0.80 | 16 | empty |
| 4 | 116 | 0.41 | 0.76 | 21 | empty |
| 5 | 125 | 0.41 | 0.76 | 25 | empty |
Interfaces
3 interfaces between chains.
- B–D · 763 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 735 Ų buried · 8 hydrogen bonds · protein-protein
- B–A · 512 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 2BAP · Crystal structure of the N-terminal mDia1 Armadillo Repeat Region and Dimerisation Domain… · the same entry in another collection · chain C against C, TM-score 1.00
- O08808 · AlphaFold monomer V2.0 prediction for protein diaphanous homolog 1 (O08808) · a predicted model of the same protein · chain A against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O08808
- Elsewhere: RCSB PDB 2BAP · PDBe 2BAP · UniProt O08808
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