UniProt O08808
Protein diaphanous homolog 1 (O08808)
Protein diaphanous homolog 1 (UniProt O08808): 21 experimental structures and 1 predicted model on GenesisL1, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O08808
- Protein
- Protein diaphanous homolog 1
- Experimental structures
- 21
- Predicted models
- 1
- Pockets
- 2 · 1 record with a druggable one
Structures
22 records of O08808 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1V9D | Crystal structure of the core FH2 domain of mouse mDia1 | x-ray diffraction | A, B, C, D | — | — |
| 1V9D | Crystal structure of the core FH2 domain of mouse MDIA1 | x-ray diffraction | A, B, C, D | — | — |
| 1Z2C | Crystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP | x-ray diffraction | B, D | — | — |
| 1Z2C | Crystal structure of MDIA1 gbd-FH3 in complex with rhoc-gmppnp | x-ray diffraction | B, D | — | — |
| 2BAP | Crystal structure of the N-terminal mDia1 Armadillo Repeat Region and Dimerisation Domain in… | x-ray diffraction | B, A, D, C | — | — |
| 2BAP | Crystal structure of the N-terminal MDIA1 armadillo repeat region and dimerisation domain in… | x-ray diffraction | B, A, D, C | — | — |
| 2BNX | Crystal structure of the dimeric regulatory domain of mouse diaphaneous-related formin (DRF), mDia1 | x-ray diffraction | A, B | — | — |
| 2BNX | Crystal structure of the dimeric regulatory domain of mouse diaphaneous-related formin (drf), MDIA1 | x-ray diffraction | A, B | — | — |
| 2F31 | Crystal structure of the autoinhibitory switch in Formin mDia1; the DID/DAD complex | x-ray diffraction | A, B | — | — |
| 2F31 | Crystal structure of the autoinhibitory switch in formin MDIA1; the DID/DAD complex | x-ray diffraction | A, B | — | — |
| 2V8F | Mouse Profilin IIa in complex with a double repeat from the FH1 domain of mDia1 | x-ray diffraction | C | — | — |
| 2V8F | Mouse profilin iia in complex with a double repeat from the FH1 domain of MDIA1 | x-ray diffraction | C | — | — |
| 3EG5 | Crystal structure of MDIA1-TSH GBD-FH3 in complex with CDC42-GMPPNP | x-ray diffraction | B, D | — | — |
| 3EG5 | Crystal structure of MDIA1-tsh gbd-FH3 in complex with CDC42-gmppnp | x-ray diffraction | B, D | — | — |
| 3O4X | Crystal structure of complex between amino and carboxy terminal fragments of mDia1 | x-ray diffraction | A, B, C, D, E, H, G, F | — | — |
| 3O4X | Crystal structure of complex between amino and carboxy terminal fragments of MDIA1 | x-ray diffraction | A, B, C, D, E, H, G, F | — | — |
| 3OBV | Autoinhibited Formin mDia1 Structure | x-ray diffraction | A, E, B, F, C, G, D, H | — | — |
| 3OBV | Autoinhibited formin MDIA1 structure | x-ray diffraction | A, E, B, F, C, G, D, H | — | — |
| 4UWX | Structure of liprin-alpha3 in complex with mDia1 Diaphanous- inhibitory domain | x-ray diffraction | A, B | — | — |
| 4UWX | Structure of liprin-ALPHA3 in complex with MDIA1 diaphanous- inhibitory domain | x-ray diffraction | A, B | — | — |
| 9B27 | Dia1 at the Barbed End of F-Actin | electron microscopy | G, H | — | 2 (best 0.67) |
| O08808 | AlphaFold monomer V2.0 prediction for protein diaphanous homolog 1 (O08808) | predicted | A | — | — |
Experiment against prediction
- 2BNX chain B against the predicted model O08808: TM-score 0.99, RMSD 0.54 Å
- 2BNX chain B against the predicted model O08808: TM-score 0.99, RMSD 0.54 Å
- 2F31 chain A against the predicted model O08808: TM-score 0.99, RMSD 0.46 Å
- 2F31 chain A against the predicted model O08808: TM-score 0.99, RMSD 0.46 Å
- 4UWX chain B against the predicted model O08808: TM-score 0.99, RMSD 0.62 Å
- 4UWX chain B against the predicted model O08808: TM-score 0.99, RMSD 0.62 Å
- 4UWX chain A against the predicted model O08808: TM-score 0.98, RMSD 1.25 Å
- 4UWX chain A against the predicted model O08808: TM-score 0.98, RMSD 1.25 Å
- 1V9D chain C against the predicted model O08808: TM-score 0.97, RMSD 1.24 Å
- 1V9D chain C against the predicted model O08808: TM-score 0.97, RMSD 1.24 Å
Elsewhere
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