MolNFT v1 · #31876 · protein

Solution NMR structure of protein dynein light chain 2A, cytoplasmic; northeast structural genomics consortium target HR2106

2B95: “Solution NMR structure of protein dynein light chain 2A, cytoplasmic; northeast structural genomics…”. Solution nmr, 2 pockets (best druggability 0.41). MolNFT v1 #31876 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2B95
Type: protein
Length: 192 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dynein light chain 2A
UniProt: Q9NP97
Pockets: 2 · best druggability 0.41

Structure

solution nmr · 1 distinct chain · 39% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Dynein light chain 2A	protein	96	39% helix, 29% strand	Q9NP97

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.41	0.82	11	empty
2	68	0.40	0.79	19	empty

Interfaces

1 interface between chains.

A–B · 1264 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

2B95 · Solution NMR structure of protein dynein light chain 2A, cytoplasmic; Northeast… · the same entry in another collection · chain A against A, TM-score 1.00
Q9NP97 · AlphaFold monomer V2.0 prediction for dynein light chain roadblock- type 1 (Q9NP97) · a predicted model of the same protein · chain A against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NP97
Elsewhere: RCSB PDB 2B95 · PDBe 2B95 · UniProt Q9NP97

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