MolNFT v1 · #31711 · protein
Structure of complex between E. COLI translation termination factor RF1 and the prmc methyltransferase
2B3T · Protein methyltransferase hemk: “Structure of complex between E. COLI translation termination factor RF1 and the prmc methyltransferase”. X-ray diffraction, 1 ligand (SAH), 8 pockets (best druggability 0.74). MolNFT v1 #31711 on…
- PDB
- 2B3T
- Type
- protein
- Length
- 576 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein methyltransferase hemk; Peptide chain release factor 1
- EC
- 2.1.1.-
- UniProt
- P37186, P0A7I0
- Ligands
- SAH
- Pockets
- 8 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein methyltransferase hemk (EC 2.1.1.-) | protein | 276 | 43% helix, 19% strand | P37186 |
| B | Peptide chain release factor 1 | protein | 300 | 36% helix, 23% strand | P0A7I0 |
Ligands and binding sites
- SAH · S-adenosyl-L-homocysteine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 146 | 0.74 | 0.93 | 33 | SAH |
| 2 | 232 | 0.54 | 0.77 | 25 | empty |
| 3 | 187 | 0.52 | 0.78 | 31 | empty |
| 4 | 254 | 0.49 | 0.74 | 24 | empty |
| 5 | 116 | 0.43 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1845 Ų buried · 36 hydrogen bonds · protein-protein
Compared structures
- 2B3T · Structure of complex between E. coli translation termination factor RF1 and the PrmC… · the same entry in another collection · chain A against A, TM-score 1.00
- P0A7I0 · AlphaFold monomer V2.0 prediction for peptide chain release factor RF1 (P0A7I0) · a predicted model of the same protein · chain B against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37186
- Every structure of UniProt P0A7I0
- Elsewhere: RCSB PDB 2B3T · PDBe 2B3T · UniProt P37186 · UniProt P0A7I0
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