MolNFT v1 · #31512 · protein
HDM2 in complex with a beta-hairpin
2AXI · Ubiquitin-protein ligase E3 MDM2: “HDM2 in complex with a beta-hairpin”. X-ray diffraction, 1 ligand (SO4). MolNFT v1 #31512 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2AXI
- Type
- protein
- Length
- 102 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-protein ligase E3 MDM2; Cyclic 8-mer peptide
- EC
- 6.3.2.-
- UniProt
- Q9UMT8
- Ligands
- SO4
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-protein ligase E3 MDM2 (EC 6.3.2.-) | protein | 92 | 42% helix, 22% strand | Q9UMT8 |
| B | Cyclic 8-mer peptide | protein | 10 | 0% helix, 60% strand | — |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A
- MPO · 3[N-morpholino]propane sulfonic acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 603 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 d-amino, 1 modified (D-amino acid, nonstandard).
Compared structures
- 2AXI · HDM2 in complex with a beta-hairpin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UMT8
- Elsewhere: RCSB PDB 2AXI · PDBe 2AXI · UniProt Q9UMT8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.