MolNFT v1 · #31459 · protein
Crystal structure of the beta subunit from DNA polymerase of streptococcus pyogenes
2AVT · DNA polymerase III beta subunit: “Crystal structure of the beta subunit from DNA polymerase of streptococcus pyogenes”. X-ray diffraction, 9 pockets (best druggability 0.73). MolNFT v1 #31459 on GenesisL1: 3D structure, binding…
- PDB
- 2AVT
- Type
- protein
- Length
- 743 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA polymerase III beta subunit
- EC
- 2.7.7.-
- Pockets
- 9 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 23% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA polymerase III beta subunit (EC 2.7.7.-) | protein | 372 | 23% helix, 43% strand | — |
| B | DNA polymerase III beta subunit (EC 2.7.7.-) | protein | 371 | 22% helix, 43% strand | — |
Pockets
9 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 53 | 0.73 | 0.98 | 19 | empty |
| 2 | 102 | 0.40 | 0.77 | 24 | empty |
| 3 | 94 | 0.40 | 0.77 | 22 | empty |
| 4 | 102 | 0.38 | 0.75 | 18 | empty |
| 5 | 59 | 0.37 | 0.79 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1142 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 2AVT · Crystal structure of the beta subunit from DNA polymerase of Streptococcus pyogenes · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2AVT · PDBe 2AVT
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