MolNFT v1 · #3140 · protein
The positions of his-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors
1CIM: “The positions of his-64 and a bound water in human carbonic anhydrase II upon binding three structurally…”. X-ray diffraction, 3 ligands (MMC, PTS, ZN), 1 pocket (best druggability 0.53). MolNFT v1 #3140 on GenesisL1: 3D structure…
- PDB
- 1CIM
- Type
- protein
- Length
- 256 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Carbonic anhydrase II
- EC
- 4.2.1.1
- UniProt
- P00918
- Ligands
- MMC, PTS, ZN
- Pockets
- 1 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 16% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Carbonic anhydrase II (EC 4.2.1.1) | protein | 256 | 16% helix, 30% strand | P00918 |
Ligands and binding sites
- MMC · Methyl mercury ion · ligand · chains A
- PTS · (4S-trans)-4-(amino)-5,6-dihydro-6-methyl-4H-thieno (2,3-b)thiopyran-2-sulfonamide-7,7-dioxide · ligand · chains A
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 126 | 0.53 | 0.81 | 26 | PTS |
Compared structures
- 1CIM · The positions of his-64 and a bound water in human carbonic anhydrase II upon binding… · the same entry in another collection · chain A against A, TM-score 1.00
- P00918 · AlphaFold monomer V2.0 prediction for carbonic anhydrase 2 (P00918) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00918
- Elsewhere: RCSB PDB 1CIM · PDBe 1CIM · UniProt P00918
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