MolNFT v1 · #31231 · protein
ADAM10 disintegrin and cysteine- rich domain
2AO7 · Adam 10: “ADAM10 disintegrin and cysteine- rich domain”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.40). MolNFT v1 #31231 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2AO7
- Type
- protein
- Length
- 146 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adam 10
- EC
- 3.4.24.81
- UniProt
- Q10741
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.40
Structure
x-ray diffraction · 1 distinct chain · 12% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adam 10 (EC 3.4.24.81) | protein | 146 | 12% helix, 22% strand | Q10741 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 76 | 0.40 | 0.79 | 20 | empty |
Modifications
Observed in the structure: 11 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q10741
- Elsewhere: RCSB PDB 2AO7 · PDBe 2AO7 · UniProt Q10741
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