UniProt Q10741
Disintegrin and metalloproteinase domain-containing protein 10 (Q10741)
Disintegrin and metalloproteinase domain-containing protein 10 (UniProt Q10741), EC 3.4.24.81: 5 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 3 pockets. Binding sites, druggability and experiment…
- UniProt
- Q10741
- Protein
- Disintegrin and metalloproteinase domain-containing protein 10
- EC
- 3.4.24.81
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 3 · 0 records with a druggable one
Structures
6 records of Q10741 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2AO7 | Adam10 Disintegrin and cysteine- rich domain | x-ray diffraction | A | — | — |
| 2AO7 | ADAM10 disintegrin and cysteine- rich domain | x-ray diffraction | A | — | — |
| 5L0Q | Crystal structure of the complex between ADAM10 D+C domain and a conformation specific mAb 8C7. | x-ray diffraction | A, D | NAG, SO4, MG | — |
| 5L0Q | Crystal structure of the complex between ADAM10 D+C domain and a conformation specific mab 8C7. | x-ray diffraction | A, D | NAG, SO4, MG | — |
| 8GH4 | Complex of Adam 10 disentegrin cysteine rich domains with human monoclonal antibody | x-ray diffraction | E | NAG | 3 (best 0.49) |
| Q10741 | AlphaFold monomer V2.0 prediction for disintegrin and metalloproteinase domain-containing protein… | predicted | A | — | — |
Ligands
Experiment against prediction
- 5L0Q chain D against the predicted model Q10741: TM-score 0.90, RMSD 1.92 Å
- 5L0Q chain D against the predicted model Q10741: TM-score 0.90, RMSD 1.92 Å
- 2AO7 chain A against the predicted model Q10741: TM-score 0.87, RMSD 2.09 Å
- 2AO7 chain A against the predicted model Q10741: TM-score 0.87, RMSD 2.09 Å
- 5L0Q chain A against the predicted model Q10741: TM-score 0.82, RMSD 2.91 Å
- 5L0Q chain A against the predicted model Q10741: TM-score 0.82, RMSD 2.91 Å
- 8GH4 chain E against the predicted model Q10741: TM-score 0.80, RMSD 3.07 Å
Elsewhere
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