MolNFT v1 · #31079 · protein

X-ray structure of the GLUR2 ligand-binding core (S1S2J) in complex with (S)-thio-atpa at 2.2 a resolution.

2AIX · Glutamate receptor 2: “X-ray structure of the GLUR2 ligand-binding core (S1S2J) in complex with (S)-thio-atpa at 2.2 a resolution.”. X-ray diffraction, 1 ligand (U1K), 3 pockets (best druggability 0.74). MolNFT v1 #31079 on…

PDB: 2AIX
Type: protein
Length: 258 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamate receptor 2
UniProt: P19491
Ligands: U1K
Pockets: 3 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutamate receptor 2	protein	258	39% helix, 21% strand	P19491

Ligands and binding sites

U1K · (S)-2-amino-3-(3-hydroxy-5-tert-butylisothiazol-4-yl) proprionic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	80	0.74	0.97	21	U1K
2	164	0.47	0.76	27	empty
3	95	0.37	0.75	24	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2AIX · X-ray structure of the GLUR2 ligand-binding core (S1S2J) in complex with (s)-thio-atpa at… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19491
Elsewhere: RCSB PDB 2AIX · PDBe 2AIX · UniProt P19491

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