MolNFT v1 · #31049 · protein

Na+ complex of the nak channel

2AHY · Potassium channel protein: “Na+ complex of the nak channel”. X-ray diffraction, 2 ligands (NA, CA), 2 pockets (best druggability 0.72). MolNFT v1 #31049 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2AHY
Type: protein
Length: 207 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Potassium channel protein
Ligands: NA, CA
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Potassium channel protein	protein	104	79% helix, 0% strand	—
B	Potassium channel protein	protein	103	75% helix, 0% strand	—

Ligands and binding sites

NA · Sodium ion · metal · 4 copies · chains A, B
CA · Calcium ion · metal · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	545	0.72	0.80	45	empty
2	51	0.34	0.78	11	empty

Interfaces

1 interface between chains.

A–B · 1264 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

2AHY · Na+ complex of the NaK Channel · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2AHY · PDBe 2AHY

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