MolNFT v1 · #30948 · protein
A model for growth hormone receptor activation based on subunit rotation within a receptor dimer
2AEW: “A model for growth hormone receptor activation based on subunit rotation within a receptor dimer”. X-ray diffraction, 2 pockets (best druggability 0.58). MolNFT v1 #30948 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2AEW
- Type
- protein
- Length
- 377 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Growth hormone receptor
- UniProt
- P10912
- Pockets
- 2 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Growth hormone receptor | protein | 189 | 2% helix, 51% strand | P10912 |
| B | Growth hormone receptor | protein | 188 | 2% helix, 49% strand | P10912 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 174 | 0.58 | 0.82 | 24 | empty |
| 2 | 109 | 0.38 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 372 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 2AEW · A model for growth hormone receptor activation based on subunit rotation within a… · the same entry in another collection · chain A against A, TM-score 1.00
- P10912 · AlphaFold monomer V2.0 prediction for growth hormone receptor (P10912) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10912
- Elsewhere: RCSB PDB 2AEW · PDBe 2AEW · UniProt P10912
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