MolNFT v1 · #30918 · protein
Crystal structure of mlta from escherichia COLI reveals a unique lytic transglycosylase fold
2AE0 · Membrane-bound lytic murein transglycosylase a: “Crystal structure of mlta from escherichia COLI reveals a unique lytic transglycosylase fold”. X-ray diffraction, 5 pockets (best druggability 0.64). MolNFT v1 #30918 on GenesisL1: 3D…
- PDB
- 2AE0
- Type
- protein
- Length
- 335 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Membrane-bound lytic murein transglycosylase a
- EC
- 3.2.1.-
- UniProt
- P0A935
- Pockets
- 5 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| X | Membrane-bound lytic murein transglycosylase a (EC 3.2.1.-) | protein | 335 | 28% helix, 30% strand | P0A935 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 356 | 0.64 | 0.79 | 50 | empty |
| 2 | 60 | 0.57 | 0.89 | 20 | empty |
| 3 | 70 | 0.52 | 0.86 | 24 | empty |
| 4 | 179 | 0.48 | 0.76 | 31 | empty |
| 5 | 71 | 0.36 | 0.77 | 16 | ACY |
Compared structures
- 2AE0 · Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase… · the same entry in another collection · chain X against X, TM-score 1.00
- P0A935 · AlphaFold monomer V2.0 prediction for membrane-bound lytic murein transglycosylase a… · a predicted model of the same protein · chain X against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A935
- Elsewhere: RCSB PDB 2AE0 · PDBe 2AE0 · UniProt P0A935
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