MolNFT v1 · #30758 · protein
2.45 ångström crystal structure of the complex between the nuclear snorna decapping nudix hydrolase X29, manganese and GTP
2A8S · U8 snorna-binding protein X29: “2.45 ångström crystal structure of the complex between the nuclear snorna decapping nudix hydrolase X29…”. X-ray diffraction, 2 ligands (GTP, MN), 3 pockets (best druggability 0.74). MolNFT v1 #30758…
- PDB
- 2A8S
- Type
- protein
- Length
- 383 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- U8 snorna-binding protein X29
- EC
- 3.6.1.-
- UniProt
- Q569R2
- Ligands
- GTP, MN
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | U8 snorna-binding protein X29 (EC 3.6.1.-) | protein | 192 | 33% helix, 32% strand | Q569R2 |
| B | U8 snorna-binding protein X29 (EC 3.6.1.-) | protein | 191 | 34% helix, 30% strand | Q569R2 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · 2 copies · chains A, B
- MN · Manganese (II) ion · metal · 8 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 83 | 0.74 | 0.97 | 22 | empty |
| 2 | 255 | 0.56 | 0.78 | 37 | MN, GTP |
| 3 | 216 | 0.53 | 0.77 | 32 | MN, GTP |
Interfaces
1 interface between chains.
- A–B · 1378 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (alkylation).
Compared structures
- 2A8S · 2.45 Angstrom Crystal Structure of the Complex Between the Nuclear SnoRNA Decapping Nudix… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q569R2
- Elsewhere: RCSB PDB 2A8S · PDBe 2A8S · UniProt Q569R2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.