MolNFT v1 · #3074 · protein
Crystal structures of recombinant 19-kda human fibroblast collagenase complexed to itself
1CGF: “Crystal structures of recombinant 19-kda human fibroblast collagenase complexed to itself”. X-ray diffraction, 2 ligands (CA, ZN), 4 pockets (best druggability 0.56). MolNFT v1 #3074 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1CGF
- Type
- protein
- Length
- 324 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast collagenase
- EC
- 3.4.24.7
- UniProt
- P03956
- Ligands
- CA, ZN
- Pockets
- 4 · best druggability 0.56
Structure
x-ray diffraction · 1 distinct chain · 23% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Fibroblast collagenase (EC 3.4.24.7) | protein | 162 | 23% helix, 15% strand | P03956 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 315 | 0.56 | 0.76 | 39 | empty |
| 2 | 69 | 0.39 | 0.79 | 18 | ZN |
| 3 | 66 | 0.38 | 0.79 | 17 | empty |
| 4 | 59 | 0.34 | 0.77 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 231 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 1CGF · Crystal structures of recombinant 19-kda human fibroblast collagenase complexed to itself · the same entry in another collection · chain A against A, TM-score 1.00
- P03956 · AlphaFold monomer V2.0 prediction for interstitial collagenase (P03956) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03956
- Elsewhere: RCSB PDB 1CGF · PDBe 1CGF · UniProt P03956
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