MolNFT v1 · #3073 · protein

Crystal structures of recombinant 19-kda human fibroblast collagenase complexed to itself

1CGE: “Crystal structures of recombinant 19-kda human fibroblast collagenase complexed to itself”. X-ray diffraction, 2 ligands (CA, ZN), 2 pockets (best druggability 0.37). MolNFT v1 #3073 on GenesisL1: 3D structure, binding sites and…

PDB: 1CGE
Type: protein
Length: 162 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fibroblast collagenase
EC: 3.4.24.7
UniProt: P03956
Ligands: CA, ZN
Pockets: 2 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 24% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fibroblast collagenase (EC 3.4.24.7)	protein	162	24% helix, 15% strand	P03956

Ligands and binding sites

CA · Calcium ion · metal · 3 copies · chains A
ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	51	0.37	0.80	16	empty
2	58	0.29	0.74	20	empty

Compared structures

1CGE · Crystal structures of recombinant 19-kda human fibroblast collagenase complexed to itself · the same entry in another collection · chain A against A, TM-score 1.00
P03956 · AlphaFold monomer V2.0 prediction for interstitial collagenase (P03956) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03956
Elsewhere: RCSB PDB 1CGE · PDBe 1CGE · UniProt P03956

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.