MolNFT v1 · #30586 · protein

The structure of T6 bovine insulin

2A3G: “The structure of T6 bovine insulin”. X-ray diffraction, 1 ligand (ZN). MolNFT v1 #30586 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2A3G
Type: protein
Length: 102 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin
UniProt: P01317
Ligands: ZN

Structure

x-ray diffraction · 2 distinct chains · 55% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Insulin	protein	21	67% helix, 10% strand	P01317
B, D	Insulin	protein	30	47% helix, 13% strand	P01317

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

5 interfaces between chains.

C–D · 913 Å² buried · 10 hydrogen bonds · protein-protein
A–B · 873 Å² buried · 13 hydrogen bonds · protein-protein
B–D · 655 Å² buried · 7 hydrogen bonds · protein-protein
B–C · 56 Å² buried · 1 hydrogen bond · protein-protein
A–D · 40 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

2A3G · The structure of T6 bovine insulin · the same entry in another collection · chain A against A, TM-score 1.00
P01317 · AlphaFold monomer V2.0 prediction for insulin (P01317) · a predicted model of the same protein · chain B against A, TM-score 0.41

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01317
Elsewhere: RCSB PDB 2A3G · PDBe 2A3G · UniProt P01317

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