MolNFT v1 · #30270 · protein

Amino terminal domain of enzyme I from escherichia COLI

1ZYM: “Amino terminal domain of enzyme I from escherichia COLI”. X-ray diffraction, 3 pockets (best druggability 0.59). MolNFT v1 #30270 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1ZYM
Type: protein
Length: 495 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Enzyme I
EC: 2.7.3.9
UniProt: P08839
Pockets: 3 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 52% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Enzyme I (EC 2.7.3.9)	protein	247	54% helix, 11% strand	P08839
B	Enzyme I (EC 2.7.3.9)	protein	248	50% helix, 13% strand	P08839

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	270	0.59	0.79	33	empty
2	150	0.42	0.74	29	empty
3	118	0.38	0.74	21	empty

Interfaces

1 interface between chains.

A–B · 430 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

1ZYM · Amino terminal domain of enzyme I from escherichia COLI · the same entry in another collection · chain A against A, TM-score 1.00
P08839 · AlphaFold monomer V2.0 prediction for phosphoenolpyruvate-protein phosphotransferase… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08839
Elsewhere: RCSB PDB 1ZYM · PDBe 1ZYM · UniProt P08839

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