MolNFT v1 · #30260 · protein
Crystal structure of EIF2ALPHA protein kinase GCN2: wild-type in apo form.
1ZYC · SERINE/THREONINE-protein kinase GCN2: “Crystal structure of EIF2ALPHA protein kinase GCN2: wild-type in apo form.”. X-ray diffraction, 9 pockets (best druggability 0.70). MolNFT v1 #30260 on GenesisL1: 3D structure, binding sites…
- PDB
- 1ZYC
- Type
- protein
- Length
- 1,042 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase GCN2
- EC
- 2.7.1.37
- UniProt
- P15442
- Pockets
- 9 · best druggability 0.70
Structure
x-ray diffraction · 4 distinct chains · 36% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase GCN2 (EC 2.7.1.37) | protein | 261 | 36% helix, 18% strand | P15442 |
| B | SERINE/THREONINE-protein kinase GCN2 (EC 2.7.1.37) | protein | 254 | 35% helix, 18% strand | P15442 |
| C | SERINE/THREONINE-protein kinase GCN2 (EC 2.7.1.37) | protein | 271 | 35% helix, 17% strand | P15442 |
| D | SERINE/THREONINE-protein kinase GCN2 (EC 2.7.1.37) | protein | 256 | 36% helix, 17% strand | P15442 |
Pockets
9 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 607 | 0.70 | 0.79 | 49 | empty |
| 2 | 439 | 0.70 | 0.81 | 59 | empty |
| 3 | 540 | 0.70 | 0.79 | 56 | empty |
| 4 | 316 | 0.65 | 0.80 | 28 | empty |
| 5 | 410 | 0.63 | 0.78 | 46 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1296 Ų buried · 22 hydrogen bonds · protein-protein
- A–B · 1191 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 481 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 1ZYC · Crystal Structure of eIF2alpha Protein Kinase GCN2: Wild-Type in Apo Form. · the same entry in another collection · chain B against B, TM-score 1.00
- P15442 · AlphaFold monomer V2.0 prediction for eif-2-alpha kinase GCN2 (P15442) · a predicted model of the same protein · chain D against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15442
- Elsewhere: RCSB PDB 1ZYC · PDBe 1ZYC · UniProt P15442
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