MolNFT v1 · #29999 · protein
Crystal structure of human dimethyladenosine transferase
1ZQ9 · Probable dimethyladenosine transferase: “Crystal structure of human dimethyladenosine transferase”. X-ray diffraction, 1 ligand (SAM), 4 pockets (best druggability 0.70). MolNFT v1 #29999 on GenesisL1: 3D structure, binding sites…
- PDB
- 1ZQ9
- Type
- protein
- Length
- 556 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable dimethyladenosine transferase
- EC
- 2.1.1.-
- UniProt
- Q9UNQ2
- Ligands
- SAM
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Probable dimethyladenosine transferase (EC 2.1.1.-) | protein | 278 | 45% helix, 18% strand | Q9UNQ2 |
Ligands and binding sites
- SAM · S-adenosylmethionine · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 243 | 0.70 | 0.85 | 44 | SAM |
| 2 | 221 | 0.68 | 0.85 | 44 | SAM |
| 3 | 277 | 0.53 | 0.75 | 39 | empty |
| 4 | 100 | 0.40 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 355 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 1ZQ9 · Crystal structure of human Dimethyladenosine transferase · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UNQ2 · AlphaFold monomer V2.0 prediction for probable dimethyladenosine transferase (Q9UNQ2) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UNQ2
- Elsewhere: RCSB PDB 1ZQ9 · PDBe 1ZQ9 · UniProt Q9UNQ2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.