MolNFT v1 · #29868 · protein

Crystal structure of the carboxyl terminal pH domain of pleckstrin to 2.1 ångströms

1ZM0: “Crystal structure of the carboxyl terminal pH domain of pleckstrin to 2.1 ångströms”. X-ray diffraction, 1 pocket (best druggability 0.57). MolNFT v1 #29868 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1ZM0
Type: protein
Length: 194 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pleckstrin
UniProt: P08567
Pockets: 1 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 14% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pleckstrin	protein	96	15% helix, 45% strand	P08567
B	Pleckstrin	protein	98	14% helix, 44% strand	P08567

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.57	0.91	19	empty

Interfaces

1 interface between chains.

A–B · 594 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

1ZM0 · Crystal Structure of the Carboxyl Terminal PH Domain of Pleckstrin To 2.1 Angstroms · the same entry in another collection · chain A against A, TM-score 1.00
P08567 · AlphaFold monomer V2.0 prediction for pleckstrin (P08567) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08567
Elsewhere: RCSB PDB 1ZM0 · PDBe 1ZM0 · UniProt P08567

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