MolNFT v1 · #29832 · protein

Crystal structure of mouse thioredoxin reductase type 2

1ZKQ · Thioredoxin reductase 2, mitochondrial: “Crystal structure of mouse thioredoxin reductase type 2”. X-ray diffraction, 1 ligand (FAD), 5 pockets (best druggability 0.79). MolNFT v1 #29832 on GenesisL1: 3D structure, binding sites and…

PDB: 1ZKQ
Type: protein
Length: 482 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Thioredoxin reductase 2, mitochondrial
EC: 1.8.1.9
UniProt: Q9JLT4
Ligands: FAD
Pockets: 5 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9)	protein	482	34% helix, 23% strand	Q9JLT4

Ligands and binding sites

FAD · Flavin-adenine dinucleotide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1084	0.79	0.81	115	FAD
2	378	0.64	0.79	46	empty
3	86	0.42	0.78	21	empty
4	57	0.31	0.76	15	empty
5	62	0.29	0.74	16	empty

Compared structures

1ZKQ · Crystal structure of mouse thioredoxin reductase type 2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9JLT4
Elsewhere: RCSB PDB 1ZKQ · PDBe 1ZKQ · UniProt Q9JLT4

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