MolNFT v1 · #29737 · protein

Structure of yeast oxysterol binding protein OSH4 in complex with 25-hydroxycholesterol

1ZHX · KES1 protein: “Structure of yeast oxysterol binding protein OSH4 in complex with 25-hydroxycholesterol”. X-ray diffraction, 1 ligand (HC3), 8 pockets (best druggability 0.85). MolNFT v1 #29737 on GenesisL1: 3D structure, binding…

PDB: 1ZHX
Type: protein
Length: 436 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: KES1 protein
UniProt: P35844
Ligands: HC3
Pockets: 8 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	KES1 protein	protein	436	31% helix, 28% strand	P35844

Ligands and binding sites

HC3 · 25-hydroxycholesterol · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	559	0.85	0.90	56	HC3
2	108	0.51	0.81	17	empty
3	95	0.47	0.81	26	empty
4	94	0.46	0.80	21	empty
5	170	0.46	0.76	36	empty

Compared structures

1ZHX · Structure of yeast oxysterol binding protein Osh4 in complex with 25-hydroxycholesterol · the same entry in another collection · chain A against A, TM-score 1.00
P35844 · AlphaFold monomer V2.0 prediction for oxysterol-binding protein homolog 4 (P35844) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35844
Elsewhere: RCSB PDB 1ZHX · PDBe 1ZHX · UniProt P35844

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.