MolNFT v1 · #29661 · protein
Carbonic anhydrase II in complex with N-4-sulfonamidphenyl-N'-4- methylbenzosulfonylurease as sulfonamide inhibitor
1ZFK: “Carbonic anhydrase II in complex with N-4-sulfonamidphenyl-N'-4- methylbenzosulfonylurease as sulfonamide…”. X-ray diffraction, 4 ligands (NR2, BE7, ZN), 2 pockets (best druggability 0.57). MolNFT v1 #29661 on GenesisL1: 3D…
- PDB
- 1ZFK
- Type
- protein
- Length
- 256 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Carbonic anhydrase II
- EC
- 4.2.1.1
- UniProt
- P00918
- Ligands
- NR2, BE7, ZN, SO4
- Pockets
- 2 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 15% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Carbonic anhydrase II (EC 4.2.1.1) | protein | 256 | 15% helix, 31% strand | P00918 |
Ligands and binding sites
- NR2 · N-({[4-(aminosulfonyl)phenyl]amino}carbonyl)-4-methylbenzenesulfonamide · ligand · 2 copies · chains A
- BE7 · (4-carboxyphenyl)(chloro)mercury · ligand · chains A
- ZN · Zinc ion · metal · chains A
- SO4 · Sulfate ion · ion · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 148 | 0.57 | 0.82 | 27 | NR2, GOL |
| 2 | 52 | 0.26 | 0.73 | 13 | empty |
Compared structures
- 1ZFK · carbonic anhydrase II in complex with N-4-sulfonamidphenyl-N'-4-methylbenzosulfonylurease… · the same entry in another collection · chain A against A, TM-score 1.00
- P00918 · AlphaFold monomer V2.0 prediction for carbonic anhydrase 2 (P00918) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00918
- Elsewhere: RCSB PDB 1ZFK · PDBe 1ZFK · UniProt P00918
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