MolNFT v1 · #29526 · protein

Foot-and mouth disease virus serotype A1061

1ZBE · Coat protein VP1: “Foot-and mouth disease virus serotype A1061”. X-ray diffraction, 8 pockets (best druggability 0.78). MolNFT v1 #29526 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1ZBE
Type: protein
Length: 668 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Coat protein VP1; Coat protein VP2; Coat protein VP3; Coat protein VP4
UniProt: P03306
Pockets: 8 · best druggability 0.78

Structure

x-ray diffraction · 4 distinct chains · 12% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
1	Coat protein VP1	protein	191	15% helix, 30% strand	P03306
2	Coat protein VP2	protein	207	11% helix, 45% strand	P03306
3	Coat protein VP3	protein	221	8% helix, 33% strand	P03306
4	Coat protein VP4	protein	49	22% helix, 2% strand	P03306

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	713	0.78	0.83	71	empty
2	868	0.72	0.77	68	empty
3	564	0.68	0.78	52	empty
4	187	0.50	0.77	26	empty
5	158	0.47	0.76	21	empty

Interfaces

6 interfaces between chains.

1–2 · 1434 Å² buried · 22 hydrogen bonds · protein-protein
1–3 · 1124 Å² buried · 19 hydrogen bonds · protein-protein
2–3 · 850 Å² buried · 11 hydrogen bonds · protein-protein
1–4 · 777 Å² buried · 14 hydrogen bonds · protein-protein
2–4 · 233 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

1ZBE · Foot-and Mouth Disease Virus Serotype A1061 · the same entry in another collection · chain 1 against 1, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03306
Elsewhere: RCSB PDB 1ZBE · PDBe 1ZBE · UniProt P03306

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