MolNFT v1 · #29399 · protein

Free human hgprt

1Z7G · Hypoxanthine-guanine phosphoribosyltransferase: “Free human hgprt”. X-ray diffraction, 7 pockets (best druggability 0.53). MolNFT v1 #29399 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1Z7G
Type: protein
Length: 804 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hypoxanthine-guanine phosphoribosyltransferase
EC: 2.4.2.8
UniProt: P00492
Pockets: 7 · best druggability 0.53

Structure

x-ray diffraction · 4 distinct chains · 30% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)	protein	199	31% helix, 29% strand	P00492
B	Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)	protein	199	29% helix, 28% strand	P00492
C	Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)	protein	204	30% helix, 28% strand	P00492
D	Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8)	protein	202	30% helix, 30% strand	P00492

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	213	0.53	0.77	33	empty
2	177	0.50	0.77	28	empty
3	90	0.38	0.76	15	empty
4	82	0.33	0.74	28	empty
5	75	0.32	0.74	21	empty

Interfaces

2 interfaces between chains.

C–D · 835 Å² buried · 15 hydrogen bonds · protein-protein
A–B · 809 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

1Z7G · Free human HGPRT · the same entry in another collection · chain D against D, TM-score 1.00
P00492 · AlphaFold monomer V2.0 prediction for hypoxanthine-guanine phosphoribosyltransferase… · a predicted model of the same protein · chain D against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00492
Elsewhere: RCSB PDB 1Z7G · PDBe 1Z7G · UniProt P00492

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