MolNFT v1 · #29317 · protein

Parainfluenza virus 5 (SV5) hemagglutinin-neuraminidase (hn) (pH 8.0)

1Z4Y: “Parainfluenza virus 5 (SV5) hemagglutinin-neuraminidase (hn) (pH 8.0)”. X-ray diffraction, 2 ligands (NAG, CA), 2 pockets (best druggability 0.56). MolNFT v1 #29317 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1Z4Y
Type: protein
Length: 443 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hemagglutinin-neuraminidase
EC: 3.2.1.18
UniProt: P04850
Ligands: NAG, CA
Pockets: 2 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hemagglutinin-neuraminidase (EC 3.2.1.18)	protein	443	7% helix, 47% strand	P04850

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 5 copies · chains A
CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	245	0.56	0.77	37	empty
2	94	0.49	0.82	31	empty

Modifications

Observed in the structure: 6 disulfide, 3 glycan (disulfide, N-glycosylation).

Compared structures

1Z4Y · Parainfluenza Virus 5 (SV5) Hemagglutinin-Neuraminidase (HN) (pH 8.0) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04850
Elsewhere: RCSB PDB 1Z4Y · PDBe 1Z4Y · UniProt P04850

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