MolNFT v1 · #29312 · protein
Crystal structure of GLY19 and GLU60 deletion mutant of human acidic fibroblast growth factor
1Z4S · Heparin-binding growth factor 1: “Crystal structure of GLY19 and GLU60 deletion mutant of human acidic fibroblast growth factor”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.62). MolNFT v1 #29312 on GenesisL1…
- PDB
- 1Z4S
- Type
- protein
- Length
- 555 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heparin-binding growth factor 1
- UniProt
- P05230
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.62
Structure
x-ray diffraction · 3 distinct chains · 7% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heparin-binding growth factor 1 | protein | 138 | 7% helix, 39% strand | P05230 |
| B, C | Heparin-binding growth factor 1 | protein | 140 | 4% helix, 38% strand | P05230 |
| D | Heparin-binding growth factor 1 | protein | 137 | 9% helix, 42% strand | P05230 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 476 | 0.62 | 0.75 | 53 | empty |
| 2 | 141 | 0.44 | 0.76 | 24 | empty |
| 3 | 113 | 0.41 | 0.76 | 20 | empty |
| 4 | 62 | 0.29 | 0.74 | 14 | empty |
Interfaces
3 interfaces between chains.
- B–D · 425 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 418 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 130 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1Z4S · Crystal Structure of Gly19 and Glu60 deletion mutant of Human Acidic Fibroblast Growth… · the same entry in another collection · chain A against A, TM-score 1.00
- P05230 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 1 (P05230) · a predicted model of the same protein · chain D against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05230
- Elsewhere: RCSB PDB 1Z4S · PDBe 1Z4S · UniProt P05230
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