Research workbench
Crystal structure of GLY19 and GLU60 deletion mutant of human acidic fibroblast growth factor
Analyse Crystal structure of GLY19 and GLU60 deletion mutant of human acidic fibroblast… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Z4S
- Type
- protein
- Length
- 555 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heparin-binding growth factor 1
- UniProt
- P05230
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.62
Structure
x-ray diffraction · 3 distinct chains · 7% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heparin-binding growth factor 1 | protein | 138 | 7% helix, 39% strand | P05230 |
| B, C | Heparin-binding growth factor 1 | protein | 140 | 4% helix, 38% strand | P05230 |
| D | Heparin-binding growth factor 1 | protein | 137 | 9% helix, 42% strand | P05230 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 476 | 0.62 | 0.75 | 53 | empty |
| 2 | 141 | 0.44 | 0.76 | 24 | empty |
| 3 | 113 | 0.41 | 0.76 | 20 | empty |
| 4 | 62 | 0.29 | 0.74 | 14 | empty |
Interfaces
3 interfaces between chains.
- B–D · 425 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 418 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 130 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1Z4S · Crystal Structure of Gly19 and Glu60 deletion mutant of Human Acidic Fibroblast Growth… · the same entry in another collection · chain A against A, TM-score 1.00
- P05230 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 1 (P05230) · a predicted model of the same protein · chain D against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05230
- Elsewhere: RCSB PDB 1Z4S · PDBe 1Z4S · UniProt P05230
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