MolNFT v1 · #29296 · protein
Crystal structure of the GAL10 fusion protein galactose MUTAROTASE/UDP-galactose 4-epimerase from saccharomyces cerevisiae complexed with NAD, udp-glucose, and galactose
1Z45 · GAL10 bifunctional protein: “Crystal structure of the GAL10 fusion protein galactose MUTAROTASE/UDP-galactose 4-epimerase from…”. X-ray diffraction, 4 ligands (NAD, UPG, GAL), 6 pockets (best druggability 0.79). MolNFT v1 #29296 on…
- PDB
- 1Z45
- Type
- protein
- Length
- 674 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GAL10 bifunctional protein
- EC
- 5.1.3.2, 5.1.3.3
- UniProt
- P04397
- Ligands
- NAD, UPG, GAL, NA
- Pockets
- 6 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 25% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GAL10 bifunctional protein (EC 5.1.3.2, 5.1.3.3) | protein | 674 | 25% helix, 31% strand | P04397 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · chains A
- UPG · Uridine-5'-diphosphate-glucose · ligand · chains A
- GAL · beta-D-galactopyranose · sugar · chains A
- NA · Sodium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 766 | 0.79 | 0.83 | 86 | NAD, UPG |
| 2 | 135 | 0.47 | 0.79 | 25 | GAL |
| 3 | 95 | 0.44 | 0.79 | 19 | empty |
| 4 | 72 | 0.42 | 0.80 | 20 | empty |
| 5 | 101 | 0.36 | 0.74 | 18 | empty |
Compared structures
- 1Z45 · Crystal structure of the gal10 fusion protein galactose mutarotase/UDP-galactose… · the same entry in another collection · chain A against A, TM-score 1.00
- P04397 · AlphaFold monomer V2.0 prediction for bifunctional protein GAL10 (P04397) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04397
- Elsewhere: RCSB PDB 1Z45 · PDBe 1Z45 · UniProt P04397
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