MolNFT v1 · #29134 · protein

The crystal structure of 14-3-3-sigma at 2.8 ångström resolution

1YZ5 · 14-3-3 protein sigma: “The crystal structure of 14-3-3-sigma at 2.8 ångström resolution”. X-ray diffraction, 3 pockets (best druggability 0.57). MolNFT v1 #29134 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1YZ5
Type: protein
Length: 452 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 14-3-3 protein sigma
UniProt: P31947
Pockets: 3 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	14-3-3 protein sigma	protein	223	78% helix, 0% strand	P31947
B	14-3-3 protein sigma	protein	229	76% helix, 0% strand	P31947

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	348	0.57	0.76	24	empty
2	173	0.47	0.76	28	empty
3	150	0.45	0.76	23	empty

Interfaces

1 interface between chains.

A–B · 1048 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

1YZ5 · The crystal structure of 14-3-3-sigma at 2.8 angstrom resolution · the same entry in another collection · chain A against A, TM-score 1.00
P31947 · AlphaFold monomer V2.0 prediction for 14-3-3 protein sigma (P31947) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31947
Elsewhere: RCSB PDB 1YZ5 · PDBe 1YZ5 · UniProt P31947

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