MolNFT v1 · #28924 · protein
Crystal structure of the unliganded form of GRP94, the er HSP90: basis for nucleotide-induced conformational change, GRP94N(DELTA)41 apo crystal soaked with ADP
1YT0 · Endoplasmin: “Crystal structure of the unliganded form of GRP94, the er HSP90: basis for nucleotide-induced conformational…”. X-ray diffraction, 2 ligands (ADP, MG), 2 pockets (best druggability 0.55). MolNFT v1 #28924 on GenesisL1…
- PDB
- 1YT0
- Type
- protein
- Length
- 194 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Endoplasmin
- UniProt
- P41148
- Ligands
- ADP, MG
- Pockets
- 2 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Endoplasmin | protein | 194 | 34% helix, 27% strand | P41148 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- PG4 · Tetraethylene glycol · additive · 6 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 186 | 0.55 | 0.79 | 25 | ADP |
| 2 | 88 | 0.32 | 0.73 | 20 | PG4 |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P41148
- Elsewhere: RCSB PDB 1YT0 · PDBe 1YT0 · UniProt P41148
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