MolNFT v1 · #28817 · protein
Crystal structure of yersinia protein tyrosine phosphatase at 2.5 ångströms and the complex with tungstate
1YPT · Protein-tyrosine phosphatase yersinia (catalytic domain): “Crystal structure of yersinia protein tyrosine phosphatase at 2.5 ångströms and the complex with tungstate”. X-ray diffraction, 8 pockets (best druggability 0.49). MolNFT v1…
- PDB
- 1YPT
- Type
- protein
- Length
- 558 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein-tyrosine phosphatase yersinia (catalytic domain)
- EC
- 3.1.3.48
- UniProt
- P15273
- Pockets
- 8 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein-tyrosine phosphatase yersinia (catalytic domain) (EC 3.1.3.48) | protein | 278 | 38% helix, 21% strand | P15273 |
| B | Protein-tyrosine phosphatase yersinia (catalytic domain) (EC 3.1.3.48) | protein | 280 | 38% helix, 21% strand | P15273 |
Pockets
8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 175 | 0.49 | 0.77 | 24 | empty |
| 2 | 227 | 0.48 | 0.74 | 39 | empty |
| 3 | 172 | 0.48 | 0.77 | 22 | empty |
| 4 | 125 | 0.45 | 0.78 | 22 | empty |
| 5 | 123 | 0.45 | 0.78 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 472 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
- 1YPT · Crystal structure of yersinia protein tyrosine phosphatase at 2.5 ångströms and the… · the same entry in another collection · chain B against B, TM-score 1.00
- P15273 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase yoph (P15273) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15273
- Elsewhere: RCSB PDB 1YPT · PDBe 1YPT · UniProt P15273
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