MolNFT v1 · #28777 · protein

Crystal structure of src kinase domain

1YOJ · Proto-oncogene tyrosine-protein kinase src: “Crystal structure of src kinase domain”. X-ray diffraction, 5 pockets (best druggability 0.65). MolNFT v1 #28777 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1YOJ
Type: protein
Length: 448 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proto-oncogene tyrosine-protein kinase src
EC: 2.7.1.112
UniProt: P12931
Pockets: 5 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Proto-oncogene tyrosine-protein kinase src (EC 2.7.1.112)	protein	233	42% helix, 17% strand	P12931
B	Proto-oncogene tyrosine-protein kinase src (EC 2.7.1.112)	protein	215	44% helix, 10% strand	P12931

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	481	0.65	0.77	51	empty
2	292	0.58	0.77	28	empty
3	193	0.47	0.75	30	empty
4	155	0.44	0.75	35	empty
5	77	0.36	0.76	13	empty

Interfaces

1 interface between chains.

A–B · 379 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

1YOJ · Crystal structure of Src kinase domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12931
Elsewhere: RCSB PDB 1YOJ · PDBe 1YOJ · UniProt P12931

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.