MolNFT v1 · #28193 · protein
Crystal structure of disulfide engineered porcine pancratic phospholipase A2 to group-X isozyme
1Y6P · Phospholipase A2, major isoenzyme: “Crystal structure of disulfide engineered porcine pancratic phospholipase A2 to group-X isozyme”. X-ray diffraction, 2 ligands (CA, CL), 2 pockets (best druggability 0.65). MolNFT v1 #28193 on…
- PDB
- 1Y6P
- Type
- protein
- Length
- 262 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phospholipase A2, major isoenzyme
- EC
- 3.1.1.4
- UniProt
- P00592
- Ligands
- CA, CL
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Phospholipase A2, major isoenzyme (EC 3.1.1.4) | protein | 131 | 48% helix, 8% strand | P00592 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 61 | 0.65 | 0.94 | 22 | CA |
| 2 | 177 | 0.59 | 0.81 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 631 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 1Y6P · Crystal structure of disulfide engineered porcine pancratic phospholipase a2 to group-x… · the same entry in another collection · chain A against A, TM-score 1.00
- P00592 · AlphaFold monomer V2.0 prediction for phospholipase A2, major isoenzyme (P00592) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00592
- Elsewhere: RCSB PDB 1Y6P · PDBe 1Y6P · UniProt P00592
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