MolNFT v1 · #28182 · protein
Orthorhombic glutathione S-transferase of schistosoma japonicum
1Y6E: “Orthorhombic glutathione S-transferase of schistosoma japonicum”. X-ray diffraction, 2 pockets (best druggability 0.82). MolNFT v1 #28182 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1Y6E
- Type
- protein
- Length
- 432 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutathione S-transferase
- EC
- 2.5.1.18
- UniProt
- P08515
- Pockets
- 2 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Glutathione S-transferase (EC 2.5.1.18) | protein | 216 | 50% helix, 8% strand | P08515 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 973 | 0.82 | 0.83 | 92 | empty |
| 2 | 63 | 0.53 | 0.88 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1465 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 1Y6E · Orthorhombic glutathione S-transferase of Schistosoma japonicum · the same entry in another collection · chain A against A, TM-score 1.00
- P08515 · AlphaFold monomer V2.0 prediction for glutathione S-transferase class-mu 26 kda isozyme… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08515
- Elsewhere: RCSB PDB 1Y6E · PDBe 1Y6E · UniProt P08515
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