MolNFT v1 · #28057 · protein
Structure of mammalian importin bound to the non-classical PLSCR1-nls
1Y2A · Importin alpha-2 subunit: “Structure of mammalian importin bound to the non-classical PLSCR1-nls”. X-ray diffraction, 1 pocket (best druggability 0.50). MolNFT v1 #28057 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1Y2A
- Type
- protein
- Length
- 433 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin alpha-2 subunit; Decamer fragment of phospholipid scramblase 1
- UniProt
- P52293, O15162
- Pockets
- 1 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Importin alpha-2 subunit | protein | 423 | 73% helix, 0% strand | P52293 |
| P | Decamer fragment of phospholipid scramblase 1 | protein | 10 | 0% helix, 0% strand | O15162 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 70 | 0.50 | 0.84 | 13 | empty |
Interfaces
1 interface between chains.
- C–P · 668 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 1Y2A · Structure of mammalian importin bound to the non-classical PLSCR1-NLS · the same entry in another collection · chain C against C, TM-score 1.00
- P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain C against A, TM-score 0.99
- O15162 · AlphaFold monomer V2.0 prediction for phospholipid scramblase 1 (O15162) · a predicted model of the same protein · chain P against A, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt O15162
- Elsewhere: RCSB PDB 1Y2A · PDBe 1Y2A · UniProt P52293 · UniProt O15162
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.