MolNFT v1 · #27880 · protein

Refinement of P99 beta-lactamase from enterobacter cloacae

1XX2: “Refinement of P99 beta-lactamase from enterobacter cloacae”. X-ray diffraction, 4 pockets (best druggability 0.62). MolNFT v1 #27880 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1XX2
Type: protein
Length: 718 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-lactamase
EC: 3.5.2.6
UniProt: P05364
Pockets: 4 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Beta-lactamase (EC 3.5.2.6)	protein	359	39% helix, 23% strand	P05364

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	255	0.62	0.81	42	empty
2	269	0.62	0.80	44	empty
3	101	0.34	0.73	19	empty
4	59	0.30	0.75	17	empty

Compared structures

1XX2 · Refinement of P99 beta-lactamase from Enterobacter cloacae · the same entry in another collection · chain A against A, TM-score 1.00
P05364 · AlphaFold monomer V2.0 prediction for beta-lactamase (P05364) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05364
Elsewhere: RCSB PDB 1XX2 · PDBe 1XX2 · UniProt P05364

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