MolNFT v1 · #27830 · protein

Crystal structure of rat alpha-parvalbumin D94S/G98E mutant

1XVJ · Parvalbumin alpha: “Crystal structure of rat alpha-parvalbumin D94S/G98E mutant”. X-ray diffraction, 1 ligand (CA), 1 pocket (best druggability 0.61). MolNFT v1 #27830 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1XVJ
Type: protein
Length: 218 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Parvalbumin alpha
UniProt: P02625
Ligands: CA
Pockets: 1 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 59% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Parvalbumin alpha	protein	109	59% helix, 2% strand	P02625

Ligands and binding sites

CA · Calcium ion · metal · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	299	0.61	0.79	43	empty

Interfaces

1 interface between chains.

A–B · 225 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1XVJ · Crystal Structure Of Rat alpha-Parvalbumin D94S/G98E Mutant · the same entry in another collection · chain A against A, TM-score 1.00
P02625 · AlphaFold monomer V2.0 prediction for parvalbumin alpha (P02625) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02625
Elsewhere: RCSB PDB 1XVJ · PDBe 1XVJ · UniProt P02625

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