MolNFT v1 · #27766 · protein

Structure of wildtype human UAP56

1XTI · Probable ATP-dependent RNA helicase P47: “Structure of wildtype human UAP56”. X-ray diffraction, 2 pockets (best druggability 0.67). MolNFT v1 #27766 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1XTI
Type: protein
Length: 381 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable ATP-dependent RNA helicase P47
UniProt: Q13838
Pockets: 2 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Probable ATP-dependent RNA helicase P47	protein	381	41% helix, 17% strand	Q13838

Ligands and binding sites

IPA · Isopropyl alcohol · additive · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	649	0.67	0.76	56	empty
2	74	0.38	0.78	19	empty

Compared structures

1XTI · Structure of Wildtype human UAP56 · the same entry in another collection · chain A against A, TM-score 1.00
Q13838 · AlphaFold monomer V2.0 prediction for spliceosome RNA helicase DDX39B (Q13838) · a predicted model of the same protein · chain A against A, TM-score 0.65

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13838
Elsewhere: RCSB PDB 1XTI · PDBe 1XTI · UniProt Q13838

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