MolNFT v1 · #27586 · protein
Crystal structure of CIB1, an ef-hand, integrin and kinase-binding protein
1XO5 · Calcium and integrin-binding protein 1: “Crystal structure of CIB1, an ef-hand, integrin and kinase-binding protein”. X-ray diffraction, 1 ligand (CA), 2 pockets (best druggability 0.33). MolNFT v1 #27586 on GenesisL1: 3D structure…
- PDB
- 1XO5
- Type
- protein
- Length
- 344 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium and integrin-binding protein 1
- UniProt
- Q99828
- Ligands
- CA
- Pockets
- 2 · best druggability 0.33
Structure
x-ray diffraction · 2 distinct chains · 58% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calcium and integrin-binding protein 1 | protein | 174 | 61% helix, 3% strand | Q99828 |
| B | Calcium and integrin-binding protein 1 | protein | 170 | 55% helix, 4% strand | Q99828 |
Ligands and binding sites
- CA · Calcium ion · metal · 8 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 53 | 0.33 | 0.78 | 15 | empty |
| 2 | 60 | 0.30 | 0.75 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 246 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 1XO5 · Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein · the same entry in another collection · chain A against A, TM-score 1.00
- Q99828 · AlphaFold monomer V2.0 prediction for calcium and integrin-binding protein 1 (Q99828) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99828
- Elsewhere: RCSB PDB 1XO5 · PDBe 1XO5 · UniProt Q99828
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