MolNFT v1 · #27440 · protein + DNA

Crystal structure of human POT1 bound to telomeric single- stranded DNA (ttagggttag)

1XJV · HT10 D(TTAGGGTTAG): “Crystal structure of human POT1 bound to telomeric single- stranded DNA (ttagggttag)”. X-ray diffraction, 4 pockets (best druggability 0.50). MolNFT v1 #27440 on GenesisL1: 3D structure, binding sites and…

PDB: 1XJV
Type: protein + DNA
Length: 301 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: HT10 D(TTAGGGTTAG); Protection of telomeres 1
UniProt: Q9NUX5
Pockets: 4 · best druggability 0.50

Structure

x-ray diffraction · 2 distinct chains · 21% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	HT10 D(TTAGGGTTAG)	dna	10	—	—
A	Protection of telomeres 1	protein	291	21% helix, 41% strand	Q9NUX5

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	120	0.50	0.80	26	empty
2	140	0.45	0.77	29	empty
3	71	0.34	0.76	11	empty
4	60	0.34	0.77	15	empty

Interfaces

1 interface between chains.

B–A · 1123 Å² buried · 34 hydrogen bonds · protein-nucleic

Compared structures

1XJV · Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG) · the same entry in another collection · chain B against B, TM-score 1.00
Q9NUX5 · AlphaFold monomer V2.0 prediction for protection of telomeres protein 1 (Q9NUX5) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NUX5
Elsewhere: RCSB PDB 1XJV · PDBe 1XJV · UniProt Q9NUX5

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