MolNFT v1 · #2728 · protein
Structural basis for selectivity of a small molecule, S1-binding, sub- micromolar inhibitor of urokinase type plasminogen activator
1C5M · Protein (coagulation factor X): “Structural basis for selectivity of a small molecule, S1-binding, sub- micromolar inhibitor of urokinase type…”. X-ray diffraction, 2 pockets (best druggability 0.40). MolNFT v1 #2728 on GenesisL1…
- PDB
- 1C5M
- Type
- protein
- Length
- 293 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (coagulation factor X)
- EC
- 3.4.21.6
- UniProt
- P00742
- Pockets
- 2 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 12% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | Protein (coagulation factor X) (EC 3.4.21.6) | protein | 241 | 12% helix, 35% strand | P00742 |
| F | Protein (coagulation factor X) (EC 3.4.21.6) | protein | 52 | 13% helix, 27% strand | P00742 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 101 | 0.40 | 0.76 | 25 | empty |
| 2 | 69 | 0.37 | 0.78 | 21 | empty |
Interfaces
1 interface between chains.
- D–F · 908 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 1C5M · Structural basis for selectivity of a small molecule, S1-binding, sub-micromolar… · the same entry in another collection · chain D against D, TM-score 1.00
- P00742 · AlphaFold monomer V2.0 prediction for coagulation factor X (P00742) · a predicted model of the same protein · chain D against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00742
- Elsewhere: RCSB PDB 1C5M · PDBe 1C5M · UniProt P00742
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.