MolNFT v1 · #27126 · protein
3-isopropylmalate dehydrogenase, low temperature (100K) structure
1XAA: “3-isopropylmalate dehydrogenase, low temperature (100K) structure”. X-ray diffraction, 3 pockets (best druggability 0.64). MolNFT v1 #27126 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1XAA
- Type
- protein
- Length
- 345 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3-isopropylmalate dehydrogenase
- EC
- 1.1.1.85
- UniProt
- Q5SIY4
- Pockets
- 3 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 49% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 3-isopropylmalate dehydrogenase (EC 1.1.1.85) | protein | 345 | 49% helix, 18% strand | Q5SIY4 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 103 | 0.64 | 0.89 | 21 | empty |
| 2 | 116 | 0.45 | 0.78 | 23 | empty |
| 3 | 52 | 0.27 | 0.74 | 14 | empty |
Compared structures
- 1XAA · 3-isopropylmalate dehydrogenase, low temperature (100K) structure · the same entry in another collection · chain A against A, TM-score 1.00
- Q5SIY4 · AlphaFold monomer V2.0 prediction for 3-isopropylmalate dehydrogenase (Q5SIY4) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SIY4
- Elsewhere: RCSB PDB 1XAA · PDBe 1XAA · UniProt Q5SIY4
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