MolNFT v1 · #27032 · protein
Crystal structure of the native copper homeostasis protein (cutcm) with calcium binding from shigella flexneri 2A str. 301
1X7I · Copper homeostasis protein cutc: “Crystal structure of the native copper homeostasis protein (cutcm) with calcium binding from shigella…”. X-ray diffraction, 1 ligand (CA), 4 pockets (best druggability 0.72). MolNFT v1 #27032 on…
- PDB
- 1X7I
- Type
- protein
- Length
- 474 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Copper homeostasis protein cutc
- UniProt
- P67825
- Ligands
- CA
- Pockets
- 4 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Copper homeostasis protein cutc | protein | 236 | 41% helix, 21% strand | P67825 |
| B | Copper homeostasis protein cutc | protein | 238 | 41% helix, 20% strand | P67825 |
Ligands and binding sites
- CA · Calcium ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 198 | 0.72 | 0.89 | 63 | empty |
| 2 | 138 | 0.58 | 0.84 | 30 | empty |
| 3 | 229 | 0.57 | 0.79 | 30 | empty |
| 4 | 318 | 0.57 | 0.76 | 37 | empty |
Interfaces
1 interface between chains.
- A–B · 1953 Ų buried · 41 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1X7I · Crystal structure of the native copper homeostasis protein (cutCm) with calcium binding… · the same entry in another collection · chain A against A, TM-score 1.00
- P67825 · AlphaFold monomer V2.0 prediction for copper homeostasis protein cutc (P67825) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P67825
- Elsewhere: RCSB PDB 1X7I · PDBe 1X7I · UniProt P67825
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.