MolNFT v1 · #2698 · protein
Crystal structure of the DNA nucleotide excision repair enzyme uvrb from thermus thermophilus
1C4O: “Crystal structure of the DNA nucleotide excision repair enzyme uvrb from thermus thermophilus”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.70). MolNFT v1 #2698 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1C4O
- Type
- protein
- Length
- 504 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA nucleotide excision repair enzyme uvrb
- UniProt
- Q56243
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA nucleotide excision repair enzyme uvrb | protein | 504 | 48% helix, 15% strand | Q56243 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A
- BOG · octyl beta-D-glucopyranoside · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 624 | 0.70 | 0.78 | 74 | SO4 |
| 2 | 238 | 0.61 | 0.81 | 33 | empty |
| 3 | 244 | 0.60 | 0.80 | 36 | empty |
| 4 | 55 | 0.31 | 0.76 | 12 | empty |
Compared structures
- 1C4O · Crystal structure of the DNA nucleotide excision repair enzyme uvrb from thermus… · the same entry in another collection · chain A against A, TM-score 1.00
- Q56243 · AlphaFold monomer V2.0 prediction for uvrabc system protein B (Q56243) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q56243
- Elsewhere: RCSB PDB 1C4O · PDBe 1C4O · UniProt Q56243
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