MolNFT v1 · #2696 · protein
Ornithine decarboxylase mutant (GLY121TYR)
1C4K · Protein (ornithine decarboxylase): “Ornithine decarboxylase mutant (GLY121TYR)”. X-ray diffraction, 2 ligands (PLP, GTP), 8 pockets (best druggability 0.65). MolNFT v1 #2696 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1C4K
- Type
- protein
- Length
- 728 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (ornithine decarboxylase)
- EC
- 4.1.1.17
- UniProt
- P43099
- Ligands
- PLP, GTP
- Pockets
- 8 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (ornithine decarboxylase) (EC 4.1.1.17) | protein | 728 | 40% helix, 18% strand | P43099 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 298 | 0.65 | 0.81 | 51 | PLP |
| 2 | 224 | 0.50 | 0.75 | 26 | empty |
| 3 | 72 | 0.43 | 0.81 | 20 | empty |
| 4 | 75 | 0.39 | 0.78 | 12 | empty |
| 5 | 97 | 0.39 | 0.76 | 18 | empty |
Modifications
Observed in the structure: 1 cofactor (pyridoxal phosphate Schiff base).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43099
- Elsewhere: RCSB PDB 1C4K · PDBe 1C4K · UniProt P43099
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.