MolNFT v1 · #26670 · protein

Ligand binding domain of human trkb receptor

1WWB · Protein (brain derived neurotrophic factor receptor trkb): “Ligand binding domain of human trkb receptor”. X-ray diffraction, 1 pocket (best druggability 0.34). MolNFT v1 #26670 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 1WWB
Type: protein
Length: 103 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (brain derived neurotrophic factor receptor trkb)
UniProt: Q16620
Pockets: 1 · best druggability 0.34

Structure

x-ray diffraction · 1 distinct chain · 3% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	Protein (brain derived neurotrophic factor receptor trkb)	protein	103	3% helix, 50% strand	Q16620

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	65	0.34	0.76	22	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1WWB · Ligand binding domain of human trkb receptor · the same entry in another collection · chain X against X, TM-score 1.00
Q16620 · AlphaFold monomer V2.0 prediction for BDNF/NT-3 growth factors receptor (Q16620) · a predicted model of the same protein · chain X against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16620
Elsewhere: RCSB PDB 1WWB · PDBe 1WWB · UniProt Q16620

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