MolNFT v1 · #2661 · protein

ACRP30 calcium complex

1C3H · 30 kd adipocyte complement-related protein precursor: “ACRP30 calcium complex”. X-ray diffraction, 1 ligand (CA), 6 pockets (best druggability 0.81). MolNFT v1 #2661 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1C3H
Type: protein
Length: 822 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 30 kd adipocyte complement-related protein precursor
UniProt: Q60994
Ligands: CA
Pockets: 6 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 0% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	30 kd adipocyte complement-related protein precursor	protein	137	0% helix, 53% strand	Q60994

Ligands and binding sites

CA · Calcium ion · metal · 3 copies · chains D, E, F

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	422	0.81	0.89	64	empty
2	326	0.72	0.84	25	empty
3	419	0.61	0.76	24	empty
4	73	0.36	0.77	19	empty
5	59	0.33	0.77	14	empty

Interfaces

6 interfaces between chains.

D–F · 1219 Å² buried · 27 hydrogen bonds · protein-protein
D–E · 1219 Å² buried · 28 hydrogen bonds · protein-protein
E–F · 1193 Å² buried · 29 hydrogen bonds · protein-protein
B–C · 995 Å² buried · 19 hydrogen bonds · protein-protein
A–B · 973 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

1C3H · ACRP30 calcium complex · the same entry in another collection · chain C against C, TM-score 1.00
Q60994 · AlphaFold monomer V2.0 prediction for adiponectin (Q60994) · a predicted model of the same protein · chain A against A, TM-score 0.83

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q60994
Elsewhere: RCSB PDB 1C3H · PDBe 1C3H · UniProt Q60994

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