MolNFT v1 · #26485 · protein
Structural basis for the regulation of insulin-like growth factors (igfs) by igf binding proteins (igfbps)
1WQJ · Insulin-like growth factor binding protein 4: “Structural basis for the regulation of insulin-like growth factors (igfs) by igf binding proteins (igfbps)”. X-ray diffraction, 1 pocket (best druggability 0.50). MolNFT v1 #26485 on…
- PDB
- 1WQJ
- Type
- protein
- Length
- 142 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin-like growth factor binding protein 4; Insulin-like growth factor ib
- UniProt
- P22692, P05019
- Pockets
- 1 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Insulin-like growth factor binding protein 4 | protein | 80 | 14% helix, 25% strand | P22692 |
| I | Insulin-like growth factor ib | protein | 62 | 40% helix, 16% strand | P05019 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 144 | 0.50 | 0.79 | 25 | empty |
Interfaces
1 interface between chains.
- B–I · 851 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 disulfide (disulfide).
Compared structures
- 1WQJ · Structural Basis for the Regulation of Insulin-Like Growth Factors (IGFs) by IGF Binding… · the same entry in another collection · chain B against B, TM-score 1.00
- P22692 · AlphaFold monomer V2.0 prediction for insulin-like growth factor- binding protein 4… · a predicted model of the same protein · chain B against A, TM-score 0.97
- P05019 · AlphaFold monomer V2.0 prediction for insulin-like growth factor I (P05019) · a predicted model of the same protein · chain I against A, TM-score 0.73
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22692
- Every structure of UniProt P05019
- Elsewhere: RCSB PDB 1WQJ · PDBe 1WQJ · UniProt P22692 · UniProt P05019
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